Erythropoietin protection effects against ischemia-reperfusion injuries during coronary artery bypass graft surgery: a randomized, double blinded, placebo control study

نویسندگان

  • SH Ziabakhsh Tabary
  • F Mokhtari-Esbui
چکیده

Background Although the rapid reperfusion by coronary artery bypass graft (CABG) surgery has significant success and it can cause decrease in mortality and morbidity rate, but this reperfusion paradoxically can cause ionic and metabolic damage that lead to myocardial damage and myocytes death. We examined whether perioperative exogenous erythropoietin (EPO) can reduce myocardial damage by reducing troponin I and creatine kinase (CKMB) level.

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منابع مشابه

Echocardiographic Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing Ischemia-Reperfusion Injuries during Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study

Background: Erythropoietin (EPO) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. Some studies have shown that EPO exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. Using echocardiography, we evaluated the effect of EPO infusion on reducing ischemia-reperfusion injuries and improvement of the cardiac func...

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Echocardiographic evaluation of a single bolus of erythropoietin effects on reducing ischemia-reperfusion injuries during coronary artery bypass graft surgery. A randomized, double blinded placebo control study

Background Erythropoietin (EPO) is known as a regulating hormone for production of red blood cells called Erythropoiesis. Some studies have shown that erythropoietin have some nonhematopoietic protective effects on ischemia-reperfusion injury in myocardial cells. We evaluated the effect of exogenous EPO infusion on reducing ischemia-reperfusion injuries and improvement of cardiac function by ec...

متن کامل

Echocardiographic Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing Ischemia-Reperfusion Injuries during Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study

BACKGROUND Erythropoietin (EPO) is known as a regulating hormone for the production of red blood cells, called erythropoiesis. Some studies have shown that EPO exerts some non-hematopoietic protective effects on ischemia-reperfusion injuries in myocytes. Using echocardiography, we evaluated the effect of EPO infusion on reducing ischemia-reperfusion injuries and improvement of the cardiac funct...

متن کامل

بررسی تأثیر درازمدت اریتروپوئتین در کاهش آسیب های ناشی از ایسکمی و ریپرفوزیون حین عمل بایپس عروق کرونری

Abstract Background and purpose: Recent studies showed that erythropoietin (EPO) despite having role in hematopoiesis, has non-hematopoietic tissue protective effects on ischemia-reperfusion injury. In this study we evaluated the effects of erythropoietin on reducing ischemia-reperfusion injuries after coronary artery bypass graft surgery (CABG). Materials and methods: 60 patients that was ...

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Impact of intravenous lidocaine on myocardial injury after off-pump coronary artery surgery.

BACKGROUND Lidocaine has been demonstrated to exert cardioprotective effects against myocardial ischaemia and reperfusion injury. We evaluated whether a continuous i.v. infusion of lidocaine reduced myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB). METHODS In this randomized, double-blinded trial, 99 patients received i.v. lidocaine 2% (i.e. a 1.5...

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2013